Film Credits








Production Credits

Directed & Produced by ELIZABETH HOLDER
Co-Produced by JOSHUA CHELMO
Executive Producer CHRISTINE CASTRO
Edited by MAKO KAMITSUNA
Director of Photography DREW THOMAS
Production Sound JENNIFER RICCIARDI
Graphic Design BETSY BELL
Music Supervisor LISA BELLAMORE
Music by MUSIC BOX
Co-Producer CHAD DARNELL
Associate Producer DASHA SNYDER
Associate Producers NEIL COHEN
DAWN KALMAR
Consulting Producers PAMELA DRESSER
LYNNE E. LITT
XAN PARKER
SARA WEISFELDT
Science Advisor ROBERT L. COHEN, M.D.
Science Consultant SOLOMON H. SNYDER, M.D.
Additional Production Sound ALEX SULLIVAN
Archival Coordinator RACHEL BRYANT
Archival Researchers KATE COE
JERUSHA BHINDIE
Assistant Editor RYAN STUMPE
Additional Assistant Editors PHILIP MANGANO
ANDREW BASSETT
GUS GUARDADO
EAMON GLENNON
Animation BETSY BELL
KEITH WOFFORD
Additional Graphics PHILIP MANGANO
JAMES FITZPATRICK
Off-line Editing Facility AVER INGENUITY, LLC.
On-line Editor RUDY LOPEZ
Colorist KELLY REESE
On-line Post Facility MATCHFRAME VIDEO
On-line Project Manager STUART HEISING
Re-Recording Mixers JENNIFER RICCIARDI
MIKE POPPLETON
STEVE YEAMAN
Sound Editor CHRIS TRUEMAN
Additional Sound Editing MIKE POPPLETON
Post Sound Facility JR. SOUND CORP.
Additional Post Sound Facility WILDFIRE POST STUDIOS
Production Associate SONORA CHASE
Production Assistants MATTHEW BERNABEI
RYAN BOLGER
JOSH BURDETT
CONNOR BYERS
JASON GREY
ALEXANDER GUNTHER
KIM JU
SPENCER SIMS
JOSHUA GEN SOLONDZ
SCOTT WHITE
Transcriptionist HAVILAND STILLWELL
Production Accountant ELIZABETH PICONE VAZQUEZ
Corporate Accountant TOM PRICE
Payroll MEDIA SERVICES
Legal Services SHATZKIN & MAYER, P.C.
KAREN SHATZKIN
DEBRA MAYER
Production Insurance MOMENTOUS INSURANCE BROKERAGE
CRAIG WARREN

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Acknowledgements

The filmmaker gratefully acknowledges the following Genentech employees who were interviewed for this film:

JOHN BRADY, Ph.D.
ROBERT L. COHEN, M.D.
SUSAN DESMOND-HELLMANN, M.D., M.P.H.
GWEN FYFE, M.D.
AMY GARTNER
ARTHUR D. LEVINSON, Ph.D.
GRACIE LIEBERMAN, M.S.
GINNY PATON, Pharm.D.
KRISTIN REED
CORSEE D. SANDERS, Ph.D.
MARK SLIWKOWSKI, Ph.D.
GEOFFREY TEETER
WAI LEE WONG
The filmmaker gratefully acknowledges the participation of the following persons who were also interviewed:

STUART A. AARONSON, M.D.
ROXANNE BALES J.
MICHAEL BISHOP, M.D.
BARBARA BRADFIELD
MELODY A. COBLEIGH, M.D.
LISA M. COUSSENS, Ph.D.
JOHN G. CURD, M.D.
ROBERT L. ERWIN
ALICE F. FURGESON
HANK J. FUCHS, M.D.
SUSAN JERIAN, M.D.
BRENDA LEIN
JOHN P. McGRATH, Ph.D.
MARILYN McGREGOR
LARRY NORTON, M.D.
PEGGY REID
STEVEN SHAK, M.D. H.
MICHAEL SHEPARD, Ph.D.
DENNIS SLAMON, M.D., Ph.D.
KATHRYN E. STEIN, Ph.D.
FRANCES M. VISCO
ROBERT A. WEINBERG, Ph.D.
KATHRYN L. WILLIAMS
JANET WOLTER, M.D.

None of the above individuals are representatives of Genentech or received payment for their interviews. Their appearance is not intended as an endorsement of Genentech or Herceptin®.
The producers gratefully acknowledge the contributions of:

GRACIA BUFFLEBEN
MARTI NELSON ERWIN, M.D.
NANCY EVANS
MARY JERIAN
LINDA REYES
The producers wish to thank the following individuals and institutions that assisted in the production of this film:

Genomic Health, Inc.
JESSICA DENNING
LAURA LEBER

Genentech, Inc., South San Francisco Campus and Vacaville Campus
ZENAIDA ALEJANDRO
ROBERT BOTTOME
LUDY BRITO
MARESA CAUNT
RYAN COOK
GREG COX
MICHAEL DE LA TORRE
LISE DUMONT
MICHEL DUNLAP
SANDRA ENOS
BRIAN EVANS
NAPOLEONE FERRARA
DAVID FREED
BIJEE GEORGE
JESSICA HERNANDEZ-FAUS
CATHY HOLLENBACH
NORM KEEGAN
ROSEMARIE KELLY
KATHY KOZAK
OI-WAI LAM
LAWRENCE LAU
DANTE LEE
CLAIRE LePICHON
MAX MILLER
MARILYN MOTA
JOSHUA NEINAN
GANKA NIKOLOVA
ELIZABETH OEFFINGER
AGGIE PAGNILLO
ELIZABETH PHILLIPS
AMIT RAO
LARA RAYHER
RICHARD REINEKE
DAVID RETZLOFF E
LIZABETH ORSI REVETRIA
TRACY L. RHODES
DOLLY RIVERO-MENDIETA
DORREYAH SCHAHIN-REED
JAKE SCHUMACHER
BRUCE SEELEY
ZEJUAN SHENG
JEAN-PHILIPPE STEPHAN
STEPHEN TAM
LAURA TOLAND
ERIC TORRES
DANIEL TRAN
RUSCELYN M. TRINIDAD-O'KEEFE
BRETT VILLAGRAND
EMILY WATSON
RYAN WATTS
ERIK WILSON
MICHELLE WONG
RANDY YEN
TODD YOUNG
SHUO ZHANG

Larkspur Hotel - Union Square
JANELL DIRKSEN

Macrogenics, Inc.

Massachusetts Institute of Technology
Whitehead Institute for Biomedical Research
Ludwig Center for Molecular Oncology
CRISTIN CARR
MATT FEARER
CHRISTINE HICKEY

Memorial Sloan-Kettering Cancer Center
WENDY BONILLA
CINDY LASSO
ESTHER NAPOLITANO

Mount Sinai School of Medicine
DONNA CHIODI
ELLEN ROSENTHAL

National Breast Cancer Coalition
SUE DUCAT
MEREDITH ELKINS

Onyx Pharmaceuticals, Inc.
MARY A. KIELICH
ALEXANDRA M. SANTOS

Rush University Medical Center
KIMBERLY WATERMAN

Threshold Pharmaceuticals

University of California, Los Angeles
UCLA's Jonsson Comprehensive Cancer Center
KIM IRWIN

University of California, San Francisco
Helen Diller Family Comprehensive Cancer Center
SHARON CARMAN
JENNIFER O'BRIEN

Wilshire Oncology Medical Group, Inc.
CARY A. PRESANT, M.D.
JULIE ARROYO
HELEN YOUNG, R.N.

SIDNEY C. BOLES
VERNA M. BOLES
DZENYA ERWIN
IRYNA ERWIN
TIMOTHY ERWIN
SCOTT PATTON
KHANDAKER D. RAHMAN
LORIE SHEPARD
ARIA STEWART
The filmmaker gratefully acknowledges the following persons for providing invaluable perspective and guidance:

JIM ALBERT
HAL BARRON, M.D.
JOSÉ BASELGA, M.D.
STANLEY C. BELL, Ph.D.
SUSAN BENTLEY
MICHAEL BOORAS
JODY BOOTH
DAVID BOTSTEIN, Ph.D.
DAVID BRAMFITT
BARBARA BRENNER
MARGARET BUDD
SUSAN BURNSTINE
DANIEL CARTER
MARSHA CARTON
NINA CHOMSKY
JENNIFER COOK
DORIS COOPER
HELEN DAVIES
MARTIN DELANEY
FREDERIC DE SAUVAGE, Ph.D.
JOHN DOYLE
JOSH DUNAIEF, M.D.
DAVID EBERSMAN
CHARLIE EIGENBROT, Ph.D.
DAVID ESSAYAN, M.D.
REHANA FARRELL
STUART FELDMAN
ANDY FINE, M.D.
ELLIE FINE
LAURA FINE, M.D.
STUART L. FINE, M.D.
AMY FLOOD
CRAIG FOSTER
LILI FOSTER
JENNY GAINTNER
SUE GAINTNER
ROB GARNICK, Ph.D.
KATIE GILBERT
PAUL J. GODOWSKI, Ph.D.
JOEL GOODMAN
EITAN GORLIN
DAMON GRANDBOUCHE
BETSY HESS
DAVID HESS
ELI HESS
GEORGE HESS
SALLY HESS
SOPHIE HESS
LAWRENCE E. HOLDER, M.D.
LIZA HOLDER
NANCY HOLDER
PAUL HSU
CLARE HUMPHREYS
LAUREN KARP
OLGA KATSNELSON
HELEN KAUFFMAN
PETER KAUFFMAN
BRIAN J. KELLY, Ph.D.
BRIAN LEYLAND-JONES, M.D., Ph.D.
HENRY LOWMAN, Ph.D.
GARY E. MARCHANT, Ph.D.
BOB MASS, M.D.
DAN MEDINA
TOM MICKEL
WINTER MILLER
DAN MIRVISH
MEGAN PACE
AUDREY PENDLETON
KAREN PRANIKOFF
TOM PRANIKOFF, M.D.
ANDREW ROBBINS
JASON SCOTT ROBERT, Ph.D.
LISA ROWE
DAVID SANGER
LESLIE SHATZ
ROBIN SIEGEL
LORI SILVERBUSH
ELAINE SNYDER
EUGENE SPIRITUS, M.D.
MARGO SPIRITUS
SUSAN SPIRITUS
THOMAS P.H. TWADDELL, M.D.
F. MIGUEL VALENTI
ROZ VARON
LINDA WEISFELDT
MYRON L. WEISFELDT, M.D.
JOHN WHITING
WILLIAM YOUNG

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Archival Credits

Archival Materials courtesy of:

Adam Marcus, Ph.D., Assistant Professor, Emory Winship Cancer Institute
AHC Media, LLC
American Association for Cancer Research
AP Archive
AP/WIDE WORLD PHOTOS
The Baltimore Sun©All rights reserved
Bay Area Reporter
BBC Motion Gallery
©2007 The Biology of Cancer by Robert A. Weinberg. Published by Garland Science/Taylor & Francis LLC.
C-SPAN
Contra Costa Times
Corbis
Courtesy CNN
Daily Mail
Dow Jones & Company, Inc.
F.I.L.M. Archives
Frederic Larson/San Francisco Chronicle
Genentech, Inc.
David M. Goldenberg, Sc.D., M.D., Garden State Cancer Center, Belleview, NJ
Hearst Communications, Inc.
The Journal of Clinical Oncology articles appear courtesy of the American Society of Clinical Oncology®
Magnetic Graffiti
National Breast Cancer Coalition
Nature Publishing Group
NBC News Archives
The New England Journal of Medicine
Professional Video Associates, Inc.
Oxford University Press Science content used with permission from AAAS
STREAMLINE FILMS, INC.
Sveriges Television AB
University of California, San Francisco
University of California, Los Angeles
Wright's Reprints
Personal Photographs and Archival Materials courtesy of:

STUART A. AARONSON, M.D.
J. MICHAEL BISHOP, M.D.
BARBARA BRADFIELD
ROBERT BURNETT
JANE P. CLELAND
MELODY A. COBLEIGH, M.D.
ROBERT L. COHEN, M.D.
PAUL CARTER, Ph.D.
LISA M. COUSSENS, Ph.D.
JOHN G. CURD, M.D.
EHAB ELGRABY, M.D.
ROBERT L. ERWIN
ALICE F. FURGESON
JOAN HALL
LAWRENCE E. HOLDER, M.D.
SUSAN JERIAN, M.D.
BRENDA LEIN
ARTHUR D. LEVINSON, Ph.D.
JOHN P. McGRATH, Ph.D.
SHAHLA MASOOD, M.D.
MARILYN McGREGOR
PHIL MIGLIARESE, JR.
LEONARD PRESTA, Ph.D.
WILLIAM J. RUTTER, Ph.D.
CORSEE D. SANDERS, Ph.D.
STEVEN SHAK, M.D.
H. MICHAEL SHEPARD, Ph.D.
DENNIS SLAMON, M.D., Ph.D.
GEOFFREY TEETER
JANELLE VAN DER LINDE
FRANCES M. VISCO
ROBERT A. WEINBERG, Ph.D.
WAI LEE WONG
WILLIAM YOUNG

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Special Thanks

Very Special Thanks to:

CHRIS CASTRO
BOB COHEN
NEIL COHEN
SEAN JOHNSTON
DAWN KALMAR

and to

ART LEVINSON, who made it all possible.

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Dedication

CREATED in SPIRIT
DAVID L. HOLDER
October 16, 1972 - September 12, 2008


DEDICATED in GRATITUDE
to those who volunteer for clinical trials and
to those whose hard work, persistence and vision
will one day lead to the eradication of cancer.

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Copyright

COPYRIGHT © 2009 GENENTECH, INC. ALL RIGHTS RESERVED.
This motion picture is protected under laws of the United States and other countries.
Any unauthorized duplication, distribution, exhibition, or use of all or part
of this motion picture may result in civil liability and criminal prosecution.



Holder Productions